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Bejelentkezés
A Tudóstér funkcióinak nagy része bejelentkezés nélkül is elérhető. Bejelentkezésre az alábbi műveletekhez van szükség:
Kun, S.,
Mathomes, R. T.,
Docsa, T.,
Somsák, L.,
Hayes, J. M.:
Design and Synthesis of 3-(β-D-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential.
Molecules. 28 (7), 1-19, (cikkazonosító: 3005), 2023.
Kánya, N.,
Kun, S.,
Somsák, L.:
Glycopyranosylidene-Spiro-Morpholinones: Evaluation of the Synthetic Possibilities Based on Glyculosonamide Derivatives and a New Method for the Construction of the Morpholine Ring.
Molecules. 27 (22), 1-18, (cikkazonosító: 7785), 2022.
Sipos, Á.,
Szennyes, E.,
Hajnal, É.,
Kun, S.,
Szabó, E. K.,
Uray, K.,
Somsák, L.,
Docsa, T.,
Bokor, É.:
Dual-Target Compounds against Type 2 Diabetes Mellitus: proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors.
Pharmaceuticals. 14 (4), 1-27, 2021.
Tsagkarakou, A. S.,
Chasapi, S. A.,
Koulas, S. M.,
Tsialtas, I.,
Kyriakis, E.,
Drakou, C. E.,
Kun, S.,
Somsák, L.,
Spyroulias, G. A.,
Psarra, A. M. G.,
Leonidas, D. D.:
Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways.
European Journal of Medicinal Chemistry Reports. 3, 1-11, (cikkazonosító: 100011), 2021.
Kánya, N.,
Kun, S.,
Batta, G.,
Somsák, L.:
Glycosylation with ulosonates under Mitsunobu conditions: scope and limitations.
New J. Chem. 44 (34), 14463-14476, 2020.
Kiss, N. É.,
Nagy, P. T.,
Tóth, F. A.,
Gorliczay, E.,
Madar, L. A.,
Kun, S.,
Tamás, J.:
Improving the water management properties of different soil type.
In: A klímaváltozás kihívásai a következő évtizedekben : előadások kivonatai, Szent István Egyetem, Keszthely, 54, 2020.
Kyriakis, E.,
Karra, A. G.,
Papaioannou, O.,
Solovou, T. G. A.,
Skamnaki, V. T.,
Liggri, P. G. V.,
Zographos, S. E.,
Szennyes, E.,
Bokor, É.,
Kun, S.,
Psarra, A. M. G.,
Somsák, L.,
Leonidas, D. D.:
The architecture of hydrogen and sulfur α-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.
Bioorg. Med. Chem. 28 (1), 1-10, (cikkazonosító: 115196), 2020.
Q1
Agricultural and Biological Sciences (miscellaneous)
Q1
Chemistry (miscellaneous)
13.
Barr, D.,
Szennyes, E.,
Bokor, É.,
Al-Oanzi, Z. H.,
Moffatt, C.,
Kun, S.,
Docsa, T.,
Sipos, Á.,
Davies, M. P.,
Mathomes, R. T.,
Snape, T. J.,
Agius, L.,
Somsák, L.,
Hayes, J. M.:
Identification of C-[béta]-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: in Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.
ACS Chem. Biol. 14 (7), 1460-1470, 2019.
Kun, S.,
Begum, J.,
Kyriakis, E.,
Stamati, E. C. V.,
Barkas, T. A.,
Szennyes, E.,
Bokor, É.,
Szabó, E. K.,
Stravodimos, G. A.,
Sipos, Á.,
Docsa, T.,
Gergely, P.,
Moffatt, C.,
Patraskaki, M. S.,
Kokolaki, M. C.,
Gkerdi, A.,
Skamnaki, V. T.,
Leonidas, D. D.,
Somsák, L.,
Hayes, J. M.:
A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
Eur. J. Med. Chem. 147, 266-278, 2018.
Kyriakis, E.,
Solovou, T. G. A.,
Kun, S.,
Czifrák, K.,
Szőcs, B.,
Juhász, L.,
Bokor, É.,
Stravodimos, G. A.,
Kantsadi, A. L.,
Chatzileontiadou, D. S. M.,
Skamnaki, V. T.,
Somsák, L.,
Leonidas, D. D.:
Probing the [beta]-pocket of the active site of human liver glycogen phosphorylase with 3-(C-[beta]-D-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors.
Bioorganic Chem. 77, 485-493, 2018.
Kun, S.,
Bokor, É.,
Sipos, Á.,
Docsa, T.,
Somsák, L.:
Synthesis of New C- and N-beta-D-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase.
Molecules. 23 (3), 1-17, 2018.
Bokor, É.,
Kun, S.,
Goyard, D.,
Tóth, M.,
Praly, J. P.,
Vidal, S.,
Somsák, L.:
C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential.
Chem. Rev. 117 (3), 1687-1764, 2017.
Kaszás, T.,
Tóth, M.,
Kun, S.,
Somsák, L.:
Coupling of anhydro-aldose tosylhydrazones with hydroxy compounds and carboxylic acids: a new route for the synthesis of C-b-D-glycopyranosylmethyl ethers and esters.
RSC Adv. 7, 10454-10462, 2017.
Szabó, E. K.,
Kun, S.,
Mándi, A.,
Kurtán, T.,
Somsák, L.:
Glucopyranosylidene-Spiro-Thiazolinones: Synthetic Studies and Determination of Absolute Configuration by TDDFT-ECD Calculations.
Molecules. 22 (10), 1760-1774, 2017.
Kantsadi, A. L.,
Stravodimos, G. A.,
Kyriakis, E.,
Chatzileontiadou, D. S. M.,
Solovou, T. G. A.,
Kun, S.,
Bokor, É.,
Somsák, L.:
van der Waals interactions govern C-[beta]-D-glucopyranosyl triazoles' nM inhibitory potency in human liver glycogen phosphorylase.
J. Struct. Biol. 199 (1), 57-67, 2017.
Kantsadi, A. L.,
Bokor, É.,
Kun, S.,
Stravodimos, G. A.,
Chatzileontiadou, D. S. M.,
Leonidas, D. D.,
Juhász-Tóth, É.,
Szakács, A.,
Batta, G.,
Docsa, T.,
Gergely, P.,
Somsák, L.:
Synthetic, enzyme kinetic, and protein crystallographic studies of C-[béta]-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
Eur. J. Med. Chem. 123, 737-745, 2016.
