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Bejelentkezés
A Tudóstér funkcióinak nagy része bejelentkezés nélkül is elérhető. Bejelentkezésre az alábbi műveletekhez van szükség:
Bokor, É.,
Kecskés, D.,
Gombás, F.,
Fehér, A.,
Kardos, E.,
Dabian, A.,
Vonza, Z.,
Szennyes, E.,
Somsák, L.:
First representatives of C-glycosyl 1,2,4,5-tetrazines: synthesis of 3-beta-d-glucopyranosyl 1,2,4,5-tetrazines and their transformation into 3-beta-d-glucopyranosyl pyridazines.
New Journal of Chemistry 47 (1), 56-74, 2023.
Bokor, É.,
Ferenczi, A.,
Hashimov, M.,
Juhász-Tóth, É.,
Götz, Z.,
Zaki, A. I.,
Somsák, L.:
First Synthesis of 3-Glycopyranosyl-1,2,4-Triazines and Some Cycloadditions There of.
Molecules. 27 (22), 1-16, 2022.
Kacsir, I.,
Sipos, A.,
Bényei, A.,
Janka, E. A.,
Buglyó, P.,
Somsák, L.,
Bai, P.,
Bokor, É.:
Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models.
Int. J. Mol. Sci. 23 (2), 1-39, (cikkazonosító: 813), 2022.
Sipos, Á.,
Szennyes, E.,
Hajnal, É.,
Kun, S.,
Szabó, E. K.,
Uray, K.,
Somsák, L.,
Docsa, T.,
Bokor, É.:
Dual-Target Compounds against Type 2 Diabetes Mellitus: proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors.
Pharmaceuticals. 14 (4), 1-27, 2021.
Kacsir, I.,
Sipos, A.,
Ujlaki, G.,
Buglyó, P.,
Somsák, L.,
Bai, P.,
Bokor, É.:
Ruthenium half-sandwich type complexes with bidentate monosaccharide ligands show antineoplastic activity in ovarian cancer cell models through reactive oxygen species production.
Int. J. Mol. Sci. 221, 1-41, 2021.
Szennyes, E.,
Gyémánt, G.,
Somsák, L.,
Bokor, É.:
Synthesis of New Series of 2-C-(béta-D-glucopyranosyl)-Pyrimidines and Their Evaluation as Inhibitors of Some Glycoenzymes.
Molecules. 25 (3), 1-18, 2020.
Kyriakis, E.,
Karra, A. G.,
Papaioannou, O.,
Solovou, T. G. A.,
Skamnaki, V. T.,
Liggri, P. G. V.,
Zographos, S. E.,
Szennyes, E.,
Bokor, É.,
Kun, S.,
Psarra, A. M. G.,
Somsák, L.,
Leonidas, D. D.:
The architecture of hydrogen and sulfur α-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.
Bioorg. Med. Chem. 28 (1), 1-10, 2020.
Barr, D.,
Szennyes, E.,
Bokor, É.,
Al-Oanzi, Z. H.,
Moffatt, C.,
Kun, S.,
Docsa, T.,
Sipos, Á.,
Davies, M. P.,
Mathomes, R. T.,
Snape, T. J.,
Agius, L.,
Somsák, L.,
Hayes, J. M.:
Identification of C-[béta]-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: in Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.
ACS Chem. Biol. 14 (7), 1460-1470, 2019.
Kun, S.,
Begum, J.,
Kyriakis, E.,
Stamati, E. C. V.,
Barkas, T. A.,
Szennyes, E.,
Bokor, É.,
Szabó, E. K.,
Stravodimos, G. A.,
Sipos, Á.,
Docsa, T.,
Gergely, P.,
Moffatt, C.,
Patraskaki, M. S.,
Kokolaki, M. C.,
Gkerdi, A.,
Skamnaki, V. T.,
Leonidas, D. D.,
Somsák, L.,
Hayes, J. M.:
A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
Eur. J. Med. Chem. 147, 266-278, 2018.
Kyriakis, E.,
Solovou, T. G. A.,
Kun, S.,
Czifrák, K.,
Szőcs, B.,
Juhász, L.,
Bokor, É.,
Stravodimos, G. A.,
Kantsadi, A. L.,
Chatzileontiadou, D. S. M.,
Skamnaki, V. T.,
Somsák, L.,
Leonidas, D. D.:
Probing the [beta]-pocket of the active site of human liver glycogen phosphorylase with 3-(C-[beta]-D-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors.
Bioorganic Chem. 77, 485-493, 2018.
Kun, S.,
Bokor, É.,
Sipos, Á.,
Docsa, T.,
Somsák, L.:
Synthesis of New C- and N-beta-D-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase.
Molecules. 23 (3), 1-17, 2018.
Bokor, É.,
Kun, S.,
Goyard, D.,
Tóth, M.,
Praly, J. P.,
Vidal, S.,
Somsák, L.:
C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential.
Chem. Rev. 117 (3), 1687-1764, 2017.
Bokor, É.,
Kyriakis, E.,
Solovou, T. G. A.,
Koppány, C.,
Kantsadi, A. L.,
Szabó, E. K.,
Szakács, A.,
Stravodimos, G. A.,
Docsa, T.,
Skamnaki, V. T.,
Zographos, S. E.,
Gergely, P.,
Leonidas, D. D.,
Somsák, L.:
Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.
J. Med. Chem. 60 (22), 9251-9262, 2017.
Kantsadi, A. L.,
Stravodimos, G. A.,
Kyriakis, E.,
Chatzileontiadou, D. S. M.,
Solovou, T. G. A.,
Kun, S.,
Bokor, É.,
Somsák, L.:
van der Waals interactions govern C-[beta]-D-glucopyranosyl triazoles' nM inhibitory potency in human liver glycogen phosphorylase.
J. Struct. Biol. 199 (1), 57-67, 2017.
