Hoffka Gyula

University of Debrecen Faculty of Medicine

Department of Biochemistry and Molecular Biology

2021-

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Publications in DEA:

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Date range:

2019-2025

2025

Hoffka, G.: A venezuelai ló-láz encephalitis vírus cisztein proteázának szerkezet-alapú vizsgálata.
Biokémia. 49 (2), 26-33, 2025.

DEA

Listov, D., Vos, E., Hoffka, G., Hoch, S. Y., Berg, A., Hamer-Rogotner, S., Dym, O., Kamerlin, S. C. L., Fleishman, S. J.: Complete computational design of high-efficiency Kemp elimination enzymes.
Nature. 643 (8074), 1421-1427, 2025.

doi DEA WoS Scopus

Journal metrics:

D1 Multidisciplinary (2024)

Gutierrez-Rus, L. I., Vos, E., Pantoja-Uceda, D., Hoffka, G., Gutierrez-Cardenas, J., Ortega-Munoz, M., Risso, V. A., Jimenez, M. A., Kamerlin, S. C. L., Sanchez-Ruiz, J. M.: Enzyme Enhancement Through Computational Stability Design Targeting NMR-Determined Catalytic Hotspots.
J. Am. Chem. Soc. 147 (18), 14978-14996, 2025.

doi DEA WoS Scopus

Journal metrics:

D1 Biochemistry (2024)

D1 Catalysis (2024)

D1 Chemistry (miscellaneous) (2024)

D1 Colloid and Surface Chemistry (2024)

Hoffka, G., Hornyák, L., Székvölgyi, L., Miskei, M.: Phosphorylation of ITIM motifs drives the structural transition of indoleamine 2,3-dioxygenase 1 between enzymatic and non-enzymatic states.
Protein Sci. 34 (6), 1-13, 2025.

doi DEA WoS Scopus

Journal metrics:

D1 Biochemistry (2024)

D1 Medicine (miscellaneous) (2024)

D1 Molecular Biology (2024)

Mahdi, M., Kiarie, I. W., Mótyán, J. A., Hoffka, G., Al-Muffti, A. S., Tóth, A., Tőzsér, J.: Receptor Binding for the Entry Mechanisms of SARS-CoV-2: Insights from the Original Strain and Emerging Variants.
Viruses-Basel. 17 (5), 1-25, (article identifier: 691), 2025.

doi DEA

Journal metrics:

Q1 Infectious Diseases (2024)

Q1 Virology (2024)

2024

Kiarie, I. W., Hoffka, G., Laporte, M., Leyssen, P., Neyts, J., Tőzsér, J., Mahdi, M.: Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2.
Viruses-Basel. 16 (10), 1-15, (article identifier: 1607), 2024.

doi DEA WoS Scopus

Journal metrics:

Q1 Infectious Diseases

Q1 Virology

Hoffka, G., Mhana, S., Vas, M., Toldi, V., Mótyán, J. A., Tőzsér, J., Szabó, A.: Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog.
J. Biol. Chem. 300 (10), 1-13, (article identifier: 107763), 2024.

doi DEA WoS Scopus

Journal metrics:

Q1 Biochemistry

Q1 Cell Biology

Q1 Molecular Biology

Golda, M., Hoffka, G., Cherry, S., Tropea, J. E., Lountos, G. T., Waugh, D. S., Wlodawer, A., Tőzsér, J., Mótyán, J. A.: P1' specificity of the S219V/R203G mutant tobacco etch virus protease.
Proteins. 92 (9), 1085-1096, 2024.

doi DEA WoS Scopus

Journal metrics:

Q1 Biochemistry

Q2 Molecular Biology

Q2 Structural Biology

2023

Hoffka, G., Lountos, G. T., Needle, D., Wlodawer, A., Waugh, D. S., Tőzsér, J., Mótyán, J. A.: Self-inhibited state of Venezuelan equine encephalitis virus (VEEV) nsP2 cysteine protease: a crystallographic and molecular dynamics analysis.
J. Mol. Biol. 435 (6), 1-20, 2023.

doi DEA WoS Scopus

Journal metrics:

Q1 Structural Biology

D1 Biophysics

Q1 Molecular Biology

2022

10.

Mótyán, J. A., Mahdi, M., Hoffka, G., Tőzsér, J.: Potential Resistance of SARS-CoV-2 Main Protease (Mpro) against Protease Inhibitors: lessons Learned from HIV-1 Protease.
Int. J. Mol. Sci. 23 (7), 1-20, (article identifier: 3507), 2022.

doi DEA WoS Scopus

Journal metrics:

Q2 Catalysis

Q1 Computer Science Applications

D1 Inorganic Chemistry

Q1 Medicine (miscellaneous)

Q2 Molecular Biology

Q1 Organic Chemistry

Q1 Physical and Theoretical Chemistry

D1 Spectroscopy

2020

11.

Ambrus, V. A., Hoffka, G., Fuxreiter, M.: Asymmetric dynamic coupling promotes alternative evolutionary pathways in an enzyme dimer.
Sci. Rep. 10 (1), 1-9, (article identifier: 18866), 2020.

doi DEA WoS Scopus

Journal metrics:

D1 Multidisciplinary

12.

Bozóki, B., Mótyán, J. A., Hoffka, G., Waugh, D. S., Tőzsér, J.: Specificity Studies of the Venezuelan Equine Encephalitis Virus Non-Structural Protein 2 Protease Using Recombinant Fluorescent Substrates.
Int. J. Mol. Sci. 21 (20), 1-26, (article identifier: 7686), 2020.

doi DEA WoS Scopus

Journal metrics:

Q2 Catalysis

D1 Computer Science Applications

D1 Inorganic Chemistry

Q1 Medicine (miscellaneous)

Q2 Molecular Biology

D1 Organic Chemistry

D1 Physical and Theoretical Chemistry

D1 Spectroscopy

2019

13.

Tüű-Szabó, B., Hoffka, G., Duró, N., Fuxreiter, M.: Altered dynamics may drift pathological fibrillization in membraneless organelles.
Biochim. Biophys. Acta. Proteins Proteom. 1867 (10), 988-998, 2019.

doi DEA

Journal metrics:

Q1 Analytical Chemistry

Q2 Biochemistry

Q1 Biophysics

Q2 Molecular Biology

14.

Ferenczi, R., Illyés, T. Z., Király, S. B., Hoffka, G., Szilágyi, L., Mándi, A., Antus, S., Kurtán, T.: Evaluation of Different Synthetic Routes to (2R,3R)-3-Hydroxymethyl-2-(4-hydroxy- 3-methoxyphenyl)-1,4-Benzodioxane-6-Carbaldehyde.
Curr. Org. Chem. 23 (26), 2960-2968, 2019.

doi DEA

Journal metrics:

Q3 Organic Chemistry