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Debreceni Egyetem. Általános Orvostudományi Kar. Biokémiai és Molekuláris Biológiai Intézet / University of Debrecen. Faculty of Medicine. Department of Biochemistry and Molecular Biology
Listov, D.,
Vos, E.,
Hoffka, G.,
Hoch, S. Y.,
Berg, A.,
Hamer-Rogotner, S.,
Dym, O.,
Kamerlin, S. C. L.,
Fleishman, S. J.:
Complete computational design of high-efficiency Kemp elimination enzymes.
Nature. 643 (8074), 1421-1427, 2025.
Gutierrez-Rus, L. I.,
Vos, E.,
Pantoja-Uceda, D.,
Hoffka, G.,
Gutierrez-Cardenas, J.,
Ortega-Munoz, M.,
Risso, V. A.,
Jimenez, M. A.,
Kamerlin, S. C. L.,
Sanchez-Ruiz, J. M.:
Enzyme Enhancement Through Computational Stability Design Targeting NMR-Determined Catalytic Hotspots.
J. Am. Chem. Soc. 147 (18), 14978-14996, 2025.
van der Pol, E.,
Schlatzer, T.,
Hoffka, G.,
Di Geronimo, B.,
Eder, J.,
Schweiger, A. K.,
Karava, M.,
Gross, D.,
Fischer, R. C.,
Kracher, D.,
Kazlauskas, R.,
Miyamoto, K.,
Kamerlin, S. C. L.,
Breinbauer, R.,
Kourist, R.:
Mechanistic Elucidation and Stereochemical Consequences of Alternative Binding of Alkenyl Substrates by Engineered Arylmalonate Decarboxylase.
J. Am. Chem. Soc. 147 (43), 39271-39283, 2025.
Hoffka, G.,
Hornyák, L.,
Székvölgyi, L.,
Miskei, M.:
Phosphorylation of ITIM motifs drives the structural transition of indoleamine 2,3-dioxygenase 1 between enzymatic and non-enzymatic states.
Protein Sci. 34 (6), 1-13, 2025.
Kiarie, I. W.,
Hoffka, G.,
Laporte, M.,
Leyssen, P.,
Neyts, J.,
Tőzsér, J.,
Mahdi, M.:
Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2.
Viruses-Basel. 16 (10), 1-15, (article identifier: 1607), 2024.
Golda, M.,
Hoffka, G.,
Cherry, S.,
Tropea, J. E.,
Lountos, G. T.,
Waugh, D. S.,
Wlodawer, A.,
Tőzsér, J.,
Mótyán, J. A.:
P1' specificity of the S219V/R203G mutant tobacco etch virus protease.
Proteins. 92 (9), 1085-1096, 2024.
Hoffka, G.,
Lountos, G. T.,
Needle, D.,
Wlodawer, A.,
Waugh, D. S.,
Tőzsér, J.,
Mótyán, J. A.:
Self-inhibited state of Venezuelan equine encephalitis virus (VEEV) nsP2 cysteine protease: a crystallographic and molecular dynamics analysis.
J. Mol. Biol. 435 (6), 1-20, 2023.
Mótyán, J. A.,
Mahdi, M.,
Hoffka, G.,
Tőzsér, J.:
Potential Resistance of SARS-CoV-2 Main Protease (Mpro) against Protease Inhibitors: lessons Learned from HIV-1 Protease.
Int. J. Mol. Sci. 23 (7), 1-20, (article identifier: 3507), 2022.
Bozóki, B.,
Mótyán, J. A.,
Hoffka, G.,
Waugh, D. S.,
Tőzsér, J.:
Specificity Studies of the Venezuelan Equine Encephalitis Virus Non-Structural Protein 2 Protease Using Recombinant Fluorescent Substrates.
Int. J. Mol. Sci. 21 (20), 1-26, (article identifier: 7686), 2020.
