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Debreceni Egyetem. Általános Orvostudományi Kar. Biokémiai és Molekuláris Biológiai Intézet / University of Debrecen. Faculty of Medicine. Department of Biochemistry and Molecular Biology
Morales Granda, N. C.,
Toldi, V.,
Miczi, M.,
Lassoued, M.,
Szabó, A.:
Inhibition of mouse trypsin isoforms by SPINK1 and effect of human pancreatitis-associated mutations.
Pancreatology. 23 (4), 358-366, 2023.
Szabó, A.,
Toldi, V.,
Gazda, L. D.,
Demcsák, A.,
Tőzsér, J.,
Sahin-Tóth, M.:
Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.
J. Biol. Chem. 296, 1-13, (article identifier: 100343), 2021.
Toldi, V.,
Szabó, A.,
Sahin-Tóth, M.:
Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation.
J. Biol. Chem. 295 (11), 3447-3455, 2020.
Esteghamat, F.,
Broughton, J. S.,
Smith, E.,
Cardone, R.,
Tyagi, T.,
Guerra, M.,
Szabó, A.,
Ugwu, N.,
Mani, M. V.,
Azari, B.,
Kayingo, G.,
Chung, S.,
Fathzadeh, M.,
Weiss, E.,
Bender, J.,
Mane, S.,
Lifton, R. P.,
Adeniran, A.,
Nathanson, M. H.,
Gorelick, F. S.,
Hwa, J.,
Sahin-Tóth, M.,
Belfort-DeAguiar, R.,
Kibbey, R. G.,
Mani, A.:
CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.
Nature Genet. 51 (8), 1233-1243, 2019.
Lasher, D.,
Szabó, A.,
Masamune, A.,
Chen, J. M.,
Xiao, X.,
Whitcomb, D. C.,
Barmada, M. M.,
Ewers, M.,
Ruffert, C.,
Paliwal, S.,
Issarapu, P.,
Bhaskar, S.,
Mani, K. R.,
Chandak, G. R.,
Laumen, H.,
Masson, E.,
Kume, K.,
Hamada, S.,
Nakano, E.,
Seltsam, K.,
Bugert, P.,
Müller, T.,
Groneberg, D. A.,
Shimosegawa, T.,
Rosendahl, J.,
Férec, C.,
Lowe, M. E.,
Witt, H.,
Sahin-Tóth, M.:
Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis.
Am. J. Gastroenterol. 114 (6), 974-983, 2019.
Tóth, A. Z.,
Szabó, A.,
Hegyi, E.,
Hegyi, P. J.,
Sahin-Tóth, M.:
Detection of human elastase isoforms by the ScheBo pancreatic elastase 1 test.
Am. J. Physiol.-Gastroint. Liver Physiol. 312 (6), G606-G614, 2017.
Boros, E.,
Szabó, A.,
Zboray, K.,
Héja, D.,
Pál, G.,
Sahin-Tóth, M.:
Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes.
J. Biol. Chem. 292 (7), 2690-2702, 2017.
Szabó, A.,
Pilsak, C.,
Bence, M.,
Witt, H.,
Sahin-Tóth, M.:
Complex formation of human proelastases with procarboxypeptidases A1 and A2.
J. Biol. Chem. 291 (34), 17706-17716, 2016.
Szabó, A.,
Xiao, X.,
Haughney, M.,
Spector, A.,
Sahin-Tóth, M.,
Lowe, M. E.:
A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding.
Biochim. Biophys. Acta. Mol. Basis Dis. 1852 (7), 1372-1379, 2015.
Szabó, A.,
Ludwig, M.,
Hegyi, E.,
Szépeová, R.,
Witt, H.,
Sahin-Tóth, M.:
Mesotrypsin signature mutation in a chymotrypsin C (CTRC) variant associated with chronic pancreatitis.
J. Biol. Chem. 290 (28), 17282-17292, 2015.
Szabó, A.,
Salameh, M. A.,
Ludwig, M.,
Radisky, E. S.,
Sahin-Tóth, M.:
Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.
PLoS One. 9 (7), e102063, 2014.
D1
Agricultural and Biological Sciences (miscellaneous)
Q1
Biochemistry, Genetics and Molecular Biology (miscellaneous)
D1
Medicine (miscellaneous)
16.
Szabó, A.,
Radisky, E. S.,
Sahin-Tóth, M.:
Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.
J. Biol. Chem. 289 (8), 4753-4761, 2014.
Batra, J.,
Szabó, A.,
Caulfield, T. R.,
Soares, A. S.,
Sahin-Tóth, M.,
Radisky, E. S.:
Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation.
J. Biol. Chem. 288 (14), 9848-9859, 2013.
Witt, H.,
Beer, S.,
Rosendahl, J.,
Chen, J. M.,
Chandak, G. R.,
Masamune, A.,
Bence, M.,
Szmola, R.,
Oracz, G.,
Macek, J. M.,
Bhatia, E.,
Steigenberger, S.,
Lasher, D.,
Bühler, F.,
Delaporte, C.,
Tebbing, J.,
Ludwig, M.,
Pilsak, C.,
Saum, K.,
Bugert, P.,
Masson, E.,
Paliwal, S.,
Bhaskar, S.,
Sobczynska-Tomaszewska, A.,
Bak, D.,
Balascak, I.,
Choudhuri, G.,
Reddy, D. N.,
Rao, G. V.,
Thomas, V.,
Kume, K.,
Nakano, E.,
Kakuta, Y.,
Shimosegawa, T.,
Durko, L.,
Szabó, A.,
Schnúr, A.,
Hegyi, P. J.,
Rakonczay, Z.,
Pfützer, R.,
Schneider, A.,
Groneberg, D. A.,
Braun, M.,
Schmidt, H.,
Witt, U.,
Friess, H.,
Algül, H.,
Landt, O.,
Schuelke, M.,
Krüger, R.,
Wiedenmann, B.,
Schmidt, F.,
Zimmer, K. P.,
Kovács, P.,
Stumvoll, M.,
Blüher, M.,
Müller, T.,
Janecke, A.,
Teich, N.,
Grützmann, R.,
Schulz, H. U.,
Mössner, J.,
Keim, V.,
Löhr, M.,
Férec, C.,
Sahin-Tóth, M.:
Variants in CPA1 are strongly associated with early onset chronic pancreatitis.
Nature Genet. 45 (10), 1216-1220, 2013.
Szabó, A.,
Sahin-Tóth, M.:
Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.
FEBS J. 279 (23), 4983-4292, 2012.
Szabó, A.,
Sahin-Tóth, M.:
Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C.
J. Biol. Chem. 287 (24), 20701-20710, 2012.
Szabó, A.,
Héja, D.,
Szakács, D.,
Zboray, K.,
Kékesi, K. A.,
Radisky, E. S.,
Sahin-Tóth, M.,
Pál, G.:
High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues.
J. Biol. Chem. 286 (25), 22535-22545, 2011.
Szmola, R.,
Bence, M.,
Carpentieri, A.,
Szabó, A.,
Costello, C. E.,
Samuelson, J.,
Sahin-Tóth, M.:
Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.
J. Biol. Chem. 286 (3), 1819-1827, 2010.
Szabó, A.,
Kotormán, M.,
Laczkó, I.,
Simon, L. M.:
Improved stability and catalytic activity of chemically modified papain in aqueous organic solvents.
Process Biochem. 44 (2), 199-204, 2009.
Szabó, A.,
Kotormán, M.,
Laczkó, I.,
Simon, L. M.:
Influence of carbohydrates on stability of papain in aqueous tetrahydrofuran mixture.
J. Chem. Technol. Biotechnol. 84 (1), 133-138, 2009.
