Szabó András

1.

Hoffka, G., Mhana, S., Vas, M., Toldi, V., Mótyán, J. A., Tőzsér, J., Szabó, A.: Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog.
J. Biol. Chem. 300 (10), 1-13, (article identifier: 107763), 2024.

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Journal metrics:

Q1 Biochemistry (2023)

Q1 Cell Biology (2023)

Q1 Molecular Biology (2023)

2.

Morales Granda, N. C., Toldi, V., Miczi, M., Lassoued, M., Szabó, A.: Inhibition of mouse trypsin isoforms by SPINK1 and effect of human pancreatitis-associated mutations.
Pancreatology. 23 (4), 358-366, 2023.

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Journal metrics:

Q1 Endocrinology

Q1 Endocrinology, Diabetes and Metabolism

Q1 Gastroenterology

Q1 Hepatology

3.

Kassay, N., Toldi, V., Tőzsér, J., Szabó, A.: Cigarette smoke toxin hydroquinone and misfolding pancreatic lipase variant cooperatively promote endoplasmic reticulum stress and cell death.
PLoS One. 17 (6), 1-19, 2022.

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Q1 Multidisciplinary

4.

Szabó, A., Toldi, V., Gazda, L. D., Demcsák, A., Tőzsér, J., Sahin-Tóth, M.: Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.
J. Biol. Chem. 296, 1-13, 2021.

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Journal metrics:

D1 Biochemistry

Q1 Cell Biology

Q1 Molecular Biology

5.

Toldi, V., Kassay, N., Szabó, A.: Missense PNLIP mutations impeding pancreatic lipase secretion cause protein misfolding and endoplasmic reticulum stress.
Pancreatology. 21 (7), 1317-1325, 2021.

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Journal metrics:

Q2 Endocrinology

Q1 Endocrinology, Diabetes and Metabolism

Q1 Gastroenterology

Q2 Hepatology

6.

Toldi, V., Szabó, A., Sahin-Tóth, M.: Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation.
J. Biol. Chem. 295 (11), 3447-3455, 2020.

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Journal metrics:

D1 Biochemistry

Q1 Cell Biology

Q1 Molecular Biology

7.

Esteghamat, F., Broughton, J. S., Smith, E., Cardone, R., Tyagi, T., Guerra, M., Szabó, A., Ugwu, N., Mani, M. V., Azari, B., Kayingo, G., Chung, S., Fathzadeh, M., Weiss, E., Bender, J., Mane, S., Lifton, R. P., Adeniran, A., Nathanson, M. H., Gorelick, F. S., Hwa, J., Sahin-Tóth, M., Belfort-DeAguiar, R., Kibbey, R. G., Mani, A.: CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.
Nature Genet. 51 (8), 1233-1243, 2019.

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Journal metrics:

D1 Genetics

8.

Lasher, D., Szabó, A., Masamune, A., Chen, J. M., Xiao, X., Whitcomb, D. C., Barmada, M. M., Ewers, M., Ruffert, C., Paliwal, S., Issarapu, P., Bhaskar, S., Mani, K. R., Chandak, G. R., Laumen, H., Masson, E., Kume, K., Hamada, S., Nakano, E., Seltsam, K., Bugert, P., Müller, T., Groneberg, D. A., Shimosegawa, T., Rosendahl, J., Férec, C., Lowe, M. E., Witt, H., Sahin-Tóth, M.: Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis.
Am. J. Gastroenterol. 114 (6), 974-983, 2019.

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Journal metrics:

D1 Gastroenterology

Q1 Hepatology

9.

Tóth, A. Z., Szabó, A., Hegyi, E., Hegyi, P. J., Sahin-Tóth, M.: Detection of human elastase isoforms by the ScheBo pancreatic elastase 1 test.
Am. J. Physiol.-Gastroint. Liver Physiol. 312 (6), G606-G614, 2017.

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Journal metrics:

Q1 Gastroenterology

Q1 Hepatology

Q1 Physiology

Q1 Physiology (medical)

10.

Boros, E., Szabó, A., Zboray, K., Héja, D., Pál, G., Sahin-Tóth, M.: Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes.
J. Biol. Chem. 292 (7), 2690-2702, 2017.

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Journal metrics:

D1 Biochemistry

Q1 Cell Biology

Q1 Molecular Biology

11.

Szabó, A., Pilsak, C., Bence, M., Witt, H., Sahin-Tóth, M.: Complex formation of human proelastases with procarboxypeptidases A1 and A2.
J. Biol. Chem. 291 (34), 17706-17716, 2016.

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Journal metrics:

D1 Biochemistry

Q1 Cell Biology

Q1 Molecular Biology

12.

Szabó, A., Xiao, X., Haughney, M., Spector, A., Sahin-Tóth, M., Lowe, M. E.: A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding.
Biochim. Biophys. Acta. Mol. Basis Dis. 1852 (7), 1372-1379, 2015.

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Journal metrics:

Q1 Molecular Biology

D1 Molecular Medicine

13.

Szabó, A., Ludwig, M., Hegyi, E., Szépeová, R., Witt, H., Sahin-Tóth, M.: Mesotrypsin signature mutation in a chymotrypsin C (CTRC) variant associated with chronic pancreatitis.
J. Biol. Chem. 290 (28), 17282-17292, 2015.

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Journal metrics:

D1 Biochemistry

Q1 Cell Biology

Q1 Molecular Biology

14.

Szabó, A., Salameh, M. A., Ludwig, M., Radisky, E. S., Sahin-Tóth, M.: Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.
PLoS One. 9 (7), e102063, 2014.

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D1 Agricultural and Biological Sciences (miscellaneous)

Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous)

D1 Medicine (miscellaneous)

15.

Szabó, A., Radisky, E. S., Sahin-Tóth, M.: Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.
J. Biol. Chem. 289 (8), 4753-4761, 2014.

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Journal metrics:

D1 Biochemistry

Q1 Cell Biology

Q1 Molecular Biology

16.

Beer, S., Zhou, J., Szabó, A., Keiles, S., Chandak, G. R., Witt, H., Sahin-Tóth, M.: Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.
Gut. 62 (11), 1616-1624, 2013.

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Journal metrics:

D1 Gastroenterology

17.

Batra, J., Szabó, A., Caulfield, T. R., Soares, A. S., Sahin-Tóth, M., Radisky, E. S.: Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation.
J. Biol. Chem. 288 (14), 9848-9859, 2013.

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Journal metrics:

D1 Biochemistry

Q1 Cell Biology

Q1 Molecular Biology

18.

Witt, H., Beer, S., Rosendahl, J., Chen, J. M., Chandak, G. R., Masamune, A., Bence, M., Szmola, R., Oracz, G., Macek, J. M., Bhatia, E., Steigenberger, S., Lasher, D., Bühler, F., Delaporte, C., Tebbing, J., Ludwig, M., Pilsak, C., Saum, K., Bugert, P., Masson, E., Paliwal, S., Bhaskar, S., Sobczynska-Tomaszewska, A., Bak, D., Balascak, I., Choudhuri, G., Reddy, D. N., Rao, G. V., Thomas, V., Kume, K., Nakano, E., Kakuta, Y., Shimosegawa, T., Durko, L., Szabó, A., Schnúr, A., Hegyi, P. J., Rakonczay, Z., Pfützer, R., Schneider, A., Groneberg, D. A., Braun, M., Schmidt, H., Witt, U., Friess, H., Algül, H., Landt, O., Schuelke, M., Krüger, R., Wiedenmann, B., Schmidt, F., Zimmer, K. P., Kovács, P., Stumvoll, M., Blüher, M., Müller, T., Janecke, A., Teich, N., Grützmann, R., Schulz, H. U., Mössner, J., Keim, V., Löhr, M., Férec, C., Sahin-Tóth, M.: Variants in CPA1 are strongly associated with early onset chronic pancreatitis.
Nature Genet. 45 (10), 1216-1220, 2013.

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Journal metrics:

D1 Genetics

19.

Szabó, A., Sahin-Tóth, M.: Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.
FEBS J. 279 (23), 4983-4292, 2012.

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Journal metrics:

Q1 Biochemistry

Q2 Cell Biology

Q1 Molecular Biology

20.

Szabó, A., Sahin-Tóth, M.: Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C.
J. Biol. Chem. 287 (24), 20701-20710, 2012.

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Journal metrics:

D1 Biochemistry

Q1 Cell Biology

Q1 Molecular Biology

21.

Szabó, A., Héja, D., Szakács, D., Zboray, K., Kékesi, K. A., Radisky, E. S., Sahin-Tóth, M., Pál, G.: High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues.
J. Biol. Chem. 286 (25), 22535-22545, 2011.

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Journal metrics:

D1 Biochemistry

Q1 Cell Biology

Q1 Molecular Biology

22.

Szmola, R., Bence, M., Carpentieri, A., Szabó, A., Costello, C. E., Samuelson, J., Sahin-Tóth, M.: Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.
J. Biol. Chem. 286 (3), 1819-1827, 2010.

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Journal metrics:

D1 Biochemistry

Q1 Cell Biology

Q1 Molecular Biology

23.

Szabó, A., Kotormán, M., Laczkó, I., Simon, L. M.: Improved stability and catalytic activity of chemically modified papain in aqueous organic solvents.
Process Biochem. 44 (2), 199-204, 2009.

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Journal metrics:

Q1 Applied Microbiology and Biotechnology

Q2 Biochemistry

Q1 Bioengineering

24.

Szabó, A., Kotormán, M., Laczkó, I., Simon, L. M.: Influence of carbohydrates on stability of papain in aqueous tetrahydrofuran mixture.
J. Chem. Technol. Biotechnol. 84 (1), 133-138, 2009.

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Q2 Biotechnology

Q1 Chemical Engineering (miscellaneous)

Q1 Fuel Technology

Q2 Inorganic Chemistry

Q2 Organic Chemistry

Q2 Pollution

Q2 Renewable Energy, Sustainability and the Environment

Q1 Waste Management and Disposal

25.

Simon, L. M., Kotormán, M., Szabó, A., Nemcsók, J. G., Laczkó, I.: The effects of organic solvent/water mixtures on the structure and catalytic activity of porcine pepsin.
Process Biochem. 42 (5), 909-912, 2007.

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Journal metrics:

Q1 Applied Microbiology and Biotechnology

Q2 Biochemistry

Q1 Bioengineering

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