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Szabó András

Szabó András
University of Debrecen Faculty of Medicine
Department of Biochemistry and Molecular Biology
2022-
Name: Szabó András
Affiliation:
  • Debreceni Egyetem. Általános Orvostudományi Kar. Biokémiai és Molekuláris Biológiai Intézet / University of Debrecen. Faculty of Medicine. Department of Biochemistry and Molecular Biology
Other profiles: MTMT

Publication list

Tudóstér co-authors statistics filterable publication list
Uploaded publications:
29
Publications in DEA:
29
OA:
16
Date range:
2003-2025
2025
1.
Morales Granda, N. C., Szabó, A., Köller, Z., Pál, G., Sahin-Tóth, M.: Engineering mouse chymotrypsin B1 for improved trypsinogen degradation.
Sci Rep. 15 (1), 1-12, (article identifier: 10201), 2025.
doi DEA Scopus
Journal metrics:
Q1 Multidisciplinary (2024)
2024
2.
Hoffka, G., Mhana, S., Vas, M., Toldi, V., Mótyán, J. A., Tőzsér, J., Szabó, A.: Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog.
J. Biol. Chem. 300 (10), 1-13, (article identifier: 107763), 2024.
doi DEA WoS Scopus
Journal metrics:
Q1 Biochemistry
Q1 Cell Biology
Q1 Molecular Biology
2023
3.
Morales Granda, N. C., Toldi, V., Miczi, M., Lassoued, M., Szabó, A.: Inhibition of mouse trypsin isoforms by SPINK1 and effect of human pancreatitis-associated mutations.
Pancreatology. 23 (4), 358-366, 2023.
doi DEA Scopus
Journal metrics:
Q1 Endocrinology
Q1 Endocrinology, Diabetes and Metabolism
Q1 Gastroenterology
Q1 Hepatology
2022
4.
Kassay, N., Toldi, V., Tőzsér, J., Szabó, A.: Cigarette smoke toxin hydroquinone and misfolding pancreatic lipase variant cooperatively promote endoplasmic reticulum stress and cell death.
PLoS One. 17 (6), 1-19, (article identifier: 0269936), 2022.
doi DEA WoS Scopus
Journal metrics:
Q1 Multidisciplinary
2021
5.
Szabó, A., Toldi, V., Gazda, L. D., Demcsák, A., Tőzsér, J., Sahin-Tóth, M.: Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.
J. Biol. Chem. 296, 1-13, 2021.
doi DEA WoS Scopus
Journal metrics:
D1 Biochemistry
Q1 Cell Biology
Q1 Molecular Biology
6.
Toldi, V., Kassay, N., Szabó, A.: Missense PNLIP mutations impeding pancreatic lipase secretion cause protein misfolding and endoplasmic reticulum stress.
Pancreatology. 21 (7), 1317-1325, 2021.
doi DEA
Journal metrics:
Q2 Endocrinology
Q1 Endocrinology, Diabetes and Metabolism
Q1 Gastroenterology
Q2 Hepatology
2020
7.
Toldi, V., Szabó, A., Sahin-Tóth, M.: Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation.
J. Biol. Chem. 295 (11), 3447-3455, 2020.
doi DEA WoS Scopus
Journal metrics:
D1 Biochemistry
Q1 Cell Biology
Q1 Molecular Biology
2019
8.
Esteghamat, F., Broughton, J. S., Smith, E., Cardone, R., Tyagi, T., Guerra, M., Szabó, A., Ugwu, N., Mani, M. V., Azari, B., Kayingo, G., Chung, S., Fathzadeh, M., Weiss, E., Bender, J., Mane, S., Lifton, R. P., Adeniran, A., Nathanson, M. H., Gorelick, F. S., Hwa, J., Sahin-Tóth, M., Belfort-DeAguiar, R., Kibbey, R. G., Mani, A.: CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.
Nature Genet. 51 (8), 1233-1243, 2019.
doi DEA
Journal metrics:
D1 Genetics
9.
Lasher, D., Szabó, A., Masamune, A., Chen, J. M., Xiao, X., Whitcomb, D. C., Barmada, M. M., Ewers, M., Ruffert, C., Paliwal, S., Issarapu, P., Bhaskar, S., Mani, K. R., Chandak, G. R., Laumen, H., Masson, E., Kume, K., Hamada, S., Nakano, E., Seltsam, K., Bugert, P., Müller, T., Groneberg, D. A., Shimosegawa, T., Rosendahl, J., Férec, C., Lowe, M. E., Witt, H., Sahin-Tóth, M.: Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis.
Am. J. Gastroenterol. 114 (6), 974-983, 2019.
doi DEA WoS Scopus
Journal metrics:
D1 Gastroenterology
Q1 Hepatology
2017
10.
Tóth, A. Z., Szabó, A., Hegyi, E., Hegyi, P. J., Sahin-Tóth, M.: Detection of human elastase isoforms by the ScheBo pancreatic elastase 1 test.
Am. J. Physiol.-Gastroint. Liver Physiol. 312 (6), G606-G614, 2017.
doi DEA
Journal metrics:
Q1 Gastroenterology
Q1 Hepatology
Q1 Physiology
Q1 Physiology (medical)
11.
Boros, E., Szabó, A., Zboray, K., Héja, D., Pál, G., Sahin-Tóth, M.: Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes.
J. Biol. Chem. 292 (7), 2690-2702, 2017.
doi DEA
Journal metrics:
D1 Biochemistry
Q1 Cell Biology
Q1 Molecular Biology
2016
12.
Szabó, A., Pilsak, C., Bence, M., Witt, H., Sahin-Tóth, M.: Complex formation of human proelastases with procarboxypeptidases A1 and A2.
J. Biol. Chem. 291 (34), 17706-17716, 2016.
doi DEA
Journal metrics:
D1 Biochemistry
Q1 Cell Biology
Q1 Molecular Biology
2015
13.
Szabó, A., Xiao, X., Haughney, M., Spector, A., Sahin-Tóth, M., Lowe, M. E.: A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding.
Biochim. Biophys. Acta. Mol. Basis Dis. 1852 (7), 1372-1379, 2015.
doi DEA
Journal metrics:
Q1 Molecular Biology
D1 Molecular Medicine
14.
Szabó, A., Ludwig, M., Hegyi, E., Szépeová, R., Witt, H., Sahin-Tóth, M.: Mesotrypsin signature mutation in a chymotrypsin C (CTRC) variant associated with chronic pancreatitis.
J. Biol. Chem. 290 (28), 17282-17292, 2015.
doi DEA
Journal metrics:
D1 Biochemistry
Q1 Cell Biology
Q1 Molecular Biology
2014
15.
Szabó, A., Salameh, M. A., Ludwig, M., Radisky, E. S., Sahin-Tóth, M.: Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.
PLoS One. 9 (7), e102063, 2014.
doi DEA
Journal metrics:
D1 Agricultural and Biological Sciences (miscellaneous)
Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous)
D1 Medicine (miscellaneous)
16.
Szabó, A., Radisky, E. S., Sahin-Tóth, M.: Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.
J. Biol. Chem. 289 (8), 4753-4761, 2014.
doi DEA
Journal metrics:
D1 Biochemistry
Q1 Cell Biology
Q1 Molecular Biology
2013
17.
Beer, S., Zhou, J., Szabó, A., Keiles, S., Chandak, G. R., Witt, H., Sahin-Tóth, M.: Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.
Gut. 62 (11), 1616-1624, 2013.
doi DEA
Journal metrics:
D1 Gastroenterology
18.
Batra, J., Szabó, A., Caulfield, T. R., Soares, A. S., Sahin-Tóth, M., Radisky, E. S.: Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation.
J. Biol. Chem. 288 (14), 9848-9859, 2013.
doi DEA
Journal metrics:
D1 Biochemistry
Q1 Cell Biology
Q1 Molecular Biology
19.
Witt, H., Beer, S., Rosendahl, J., Chen, J. M., Chandak, G. R., Masamune, A., Bence, M., Szmola, R., Oracz, G., Macek, J. M., Bhatia, E., Steigenberger, S., Lasher, D., Bühler, F., Delaporte, C., Tebbing, J., Ludwig, M., Pilsak, C., Saum, K., Bugert, P., Masson, E., Paliwal, S., Bhaskar, S., Sobczynska-Tomaszewska, A., Bak, D., Balascak, I., Choudhuri, G., Reddy, D. N., Rao, G. V., Thomas, V., Kume, K., Nakano, E., Kakuta, Y., Shimosegawa, T., Durko, L., Szabó, A., Schnúr, A., Hegyi, P. J., Rakonczay, Z., Pfützer, R., Schneider, A., Groneberg, D. A., Braun, M., Schmidt, H., Witt, U., Friess, H., Algül, H., Landt, O., Schuelke, M., Krüger, R., Wiedenmann, B., Schmidt, F., Zimmer, K. P., Kovács, P., Stumvoll, M., Blüher, M., Müller, T., Janecke, A., Teich, N., Grützmann, R., Schulz, H. U., Mössner, J., Keim, V., Löhr, M., Férec, C., Sahin-Tóth, M.: Variants in CPA1 are strongly associated with early onset chronic pancreatitis.
Nature Genet. 45 (10), 1216-1220, 2013.
doi DEA
Journal metrics:
D1 Genetics
2012
20.
Szabó, A., Sahin-Tóth, M.: Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.
FEBS J. 279 (23), 4983-4292, 2012.
doi DEA
Journal metrics:
Q1 Biochemistry
Q2 Cell Biology
Q1 Molecular Biology
21.
Szabó, A., Sahin-Tóth, M.: Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C.
J. Biol. Chem. 287 (24), 20701-20710, 2012.
doi DEA
Journal metrics:
D1 Biochemistry
Q1 Cell Biology
Q1 Molecular Biology
2011
22.
Szabó, A., Héja, D., Szakács, D., Zboray, K., Kékesi, K. A., Radisky, E. S., Sahin-Tóth, M., Pál, G.: High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues.
J. Biol. Chem. 286 (25), 22535-22545, 2011.
doi DEA
Journal metrics:
D1 Biochemistry
Q1 Cell Biology
Q1 Molecular Biology
2010
23.
Szmola, R., Bence, M., Carpentieri, A., Szabó, A., Costello, C. E., Samuelson, J., Sahin-Tóth, M.: Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.
J. Biol. Chem. 286 (3), 1819-1827, 2010.
doi DEA
Journal metrics:
D1 Biochemistry
Q1 Cell Biology
Q1 Molecular Biology
2009
24.
Szabó, A., Kotormán, M., Laczkó, I., Simon, L. M.: Improved stability and catalytic activity of chemically modified papain in aqueous organic solvents.
Process Biochem. 44 (2), 199-204, 2009.
doi DEA
Journal metrics:
Q1 Applied Microbiology and Biotechnology
Q2 Biochemistry
Q1 Bioengineering
25.
Szabó, A., Kotormán, M., Laczkó, I., Simon, L. M.: Influence of carbohydrates on stability of papain in aqueous tetrahydrofuran mixture.
J. Chem. Technol. Biotechnol. 84 (1), 133-138, 2009.
doi DEA
Journal metrics:
Q2 Biotechnology
Q1 Chemical Engineering (miscellaneous)
Q1 Fuel Technology
Q2 Inorganic Chemistry
Q2 Organic Chemistry
Q2 Pollution
Q2 Renewable Energy, Sustainability and the Environment
Q1 Waste Management and Disposal
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