Synthesis of Hydroxynaphthyl-Substituted alpha-Amino Acid Derivatives via a Modified Mannich Reaction

Csütörtöki, R., Szatmári, I., Mándi, A., Kurtán, T., Fülöp, F.: Synthesis of Hydroxynaphthyl-Substituted alpha-Amino Acid Derivatives via a Modified Mannich Reaction.
Synlett. 2011 (13), 1940-1946, 2011.

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Journal metrics:

Q1 Organic Chemistry

title:

Synthesis of Hydroxynaphthyl-Substituted alpha-Amino Acid Derivatives via a Modified Mannich Reaction

authors:

Csütörtöki Renáta
Szatmári István
Mándi Attila
Kurtán Tibor
Fülöp Ferenc

published:

2011

type:

article

genre:

research article/review article

journal:

Synlett (ISSN: 0936-5214)

language:

English

HAC:

Natural Sciences, Chemical Sciences

subjects:

multicomponent reaction, amino acids, Mannich bases, enantioseparation, CD analysis

abstract:

An efficient one-pot synthesis of hydroxynaphthyl-substituted glycine derivatives from 2- or 1-naphthol, glyoxylic acid, and benzyl carbamate via a modified Mannich reaction is described. The enantiomers were successfully separated on analytical and semipreparative HPLC columns. Their absolute configurations were determined by CD analysis supported by TDDFT CD calculations.

projects:

K-68429; K-75433; K-81701