Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast

Wu, X. Y., Liu, X. H., Lin, Y. C., Luo, J. H., She, Z. G., Houjin, L., Chan, W. L., Antus, S., Kurtán, T., Elsässer, B., Krohn, K.: Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast.
Eur. J. Org. Chem. 2005 (19), 4061-4064, 2005.

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Q1 Organic Chemistry

Q1 Physical and Theoretical Chemistry

title:

Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast

authors:

Wu, Xiong Yu
Liu, Xiao Hong
Lin, Yong Cheng
Luo, Jing Hui
She, Zhi Gang
Houjin, Li
Chan, Wing Lai
Antus Sándor
Kurtán Tibor
Elsässer, Brigitta
Krohn, Karsten

published:

2005

type:

article

genre:

research article/review article

journal:

European Journal Of Organic Chemistry (ISSN: 1434-193X)

language:

English

HAC:

Natural Sciences, Chemical Sciences

subjects:

Fungal metabolites, Xylaria sp., Xyloketal F, Semi synthesis, Absolute configuration, Quantum-mechanical CD calculation, L-Calcium channel blocker

abstract:

Xyloketal F (1), an unusual metabolite with strong L-calcium channel blocking activity, was isolated from the mangrove endophytic fungus Xylaria sp. (#2508) collected at the South China Sea coast. Its structure was elucidated by spectral and single-crystal X-ray diffraction analysis. The absolute configuration of 1 was determined by the method of quantum-mechanical calculation of CD spectra. Compound 1 was also synthesized by condensation of xyloketal B with formaldehyde. The L-calcium channel blocking activities of xyloketals B, A, and F were determined, and at the same concentration (0.03 mumol/L), the inhibiting rates were 12.05%, 21.47%, and 50.33% respectively.