Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast

Wu, X. Y., Liu, X. H., Lin, Y. C., Luo, J. H., She, Z. G., Houjin, L., Chan, W. L., Antus, S., Kurtán, T., Elsässer, B., Krohn, K.: Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast.
Eur. J. Org. Chem. 2005 (19), 4061-4064, 2005.

doi DEA

Folyóirat-mutatók:

Q1 Organic Chemistry

Q1 Physical and Theoretical Chemistry

cím:

Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast

szerzők:

Wu, Xiong Yu
Liu, Xiao Hong
Lin, Yong Cheng
Luo, Jing Hui
She, Zhi Gang
Houjin, Li
Chan, Wing Lai
Antus Sándor
Kurtán Tibor
Elsässer, Brigitta
Krohn, Karsten

kiadás éve:

2005

típus:

folyóiratcikk

műfaj:

idegen nyelvű folyóiratközlemény külföldi lapban

folyóirat:

European Journal Of Organic Chemistry (ISSN: 1434-193X)

nyelv:

angol

MAB:

természettudományok, kémiai tudományok

tárgyszavak:

Fungal metabolites, Xylaria sp., Xyloketal F, Semi synthesis, Absolute configuration, Quantum-mechanical CD calculation, L-Calcium channel blocker

absztrakt:

Xyloketal F (1), an unusual metabolite with strong L-calcium channel blocking activity, was isolated from the mangrove endophytic fungus Xylaria sp. (#2508) collected at the South China Sea coast. Its structure was elucidated by spectral and single-crystal X-ray diffraction analysis. The absolute configuration of 1 was determined by the method of quantum-mechanical calculation of CD spectra. Compound 1 was also synthesized by condensation of xyloketal B with formaldehyde. The L-calcium channel blocking activities of xyloketals B, A, and F were determined, and at the same concentration (0.03 mumol/L), the inhibiting rates were 12.05%, 21.47%, and 50.33% respectively.