Varioxepine A, a 3H-Oxepine-Containing Alkaloid with a New Oxa-Cage from the Marine Algal-Derived Endophytic Fungus Paecilomyces variotii

Zhang, P., Mándi, A., Li, X. M., Du, F. Y., Wang, J. N., Li, X., Kurtán, T., Wang, B. G.: Varioxepine A, a 3H-Oxepine-Containing Alkaloid with a New Oxa-Cage from the Marine Algal-Derived Endophytic Fungus Paecilomyces variotii.
Org. Lett. 16 (18), 4834-4837, 2014.

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D1 Organic Chemistry

D1 Physical and Theoretical Chemistry

title:

Varioxepine A, a 3H-Oxepine-Containing Alkaloid with a New Oxa-Cage from the Marine Algal-Derived Endophytic Fungus Paecilomyces variotii

authors:

Zhang, Peng
Mándi Attila
Li, Xiao-Ming
Du, Feng-Yu
Wang, Jia-Ning
Li, Xin
Kurtán Tibor
Wang, Bin-Gui

corresponding author:

Kurtán Tibor

published:

2014

type:

article

genre:

research article/review article

journal:

Organic Letters (ISSN: 1523-7060)

language:

English

HAC:

Natural Sciences, Chemical Sciences

abstract:

A new 3H-oxepine-containing alkaloid, varioxepine A (1), characterized by a structurally unprecedented condensed 3,6,8-trioxabicyclo[3.2.1]octane motif, was isolated from the marine algal-derived endophytic fungus Paecilomyces variotii. Due to the low proton/carbon ratio, the unambiguous assignment of the planar structure and relative configuration was precluded by NMR experiments and solved by single crystal X-ray analysis. The absolute configuration was established by DFT conformational analysis and TDDFT-ECD calculations. Compound 1 inhibited plant pathogenic fungusFusarium graminearum.

projects:

K105871; NIIFI 10038