Pseudoanguillosporin A and B: two New Isochromans Isolated from the Endophytic Fungus Pseudoanguillospora sp.

Kock, I., Dräeger, S., Schulz, B., Elsässer, B., Kurtán, T., Kenéz, Á., Antus, S., Pescitelli, G., Salvadori, P., Speakman, J. B., Rheinheimer, J., Krohn, K.: Pseudoanguillosporin A and B: two New Isochromans Isolated from the Endophytic Fungus Pseudoanguillospora sp..
Eur. J. Org. Chem. 2009 (9), 1427-1434, 2009.

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Q1 Organic Chemistry

Q1 Physical and Theoretical Chemistry

title:

Pseudoanguillosporin A and B: two New Isochromans Isolated from the Endophytic Fungus Pseudoanguillospora sp.

authors:

Kock, Ines
Dräeger, Siegfried
Schulz, Barbara
Elsässer, Brigitta
Kurtán Tibor
Kenéz Ágnes
Antus Sándor
Pescitelli, Gennaro
Salvadori, Piero
Speakman, John-Bryan
Rheinheimer, Joachim
Krohn, Karsten

published:

2009

type:

article

genre:

research article/review article

journal:

European Journal Of Organic Chemistry (ISSN: 1434-193X)

language:

English

HAC:

Natural Sciences, Chemical Sciences

subjects:

biological activity, isochromans, natural products, circular dichroism, NMR spectroscopy

abstract:

Two new isochromans named pseudoanguillosporin A (2a) and B (3), together with the known cephalochromin (1), were isolated from Pseudoanguillospora sp. The C-2 absolute configuration of 2a and 3 was deduced from its CD spectrum by the isochroman helicity rule, supported by TDDFT CD calculations. The absolute configuration of the sec-hydroxyl group of 3 was determined by the Mosher NMR method from the MPA esters of its methylated derivative. The axial chirality of 1 was assigned through exciton analysis of its CD spectrum and confirmed by ZINDO CD calculations. The metabolites showed broad antimicrobial activities.