EN HU

In Vitro Models of Cardiovascular Calcification

Tóth, A., Balogh, E., Jeney, V.: In Vitro Models of Cardiovascular Calcification.
Biomedicines. 12 (9), 1-15, (cikkazonosító: 2155), 2024.
Folyóirat-mutatók:
Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous)
Q1 Medicine (miscellaneous)
cím:
In Vitro Models of Cardiovascular Calcification
szerzők:
  • Tóth Andrea
  • Balogh Enikő
  • Jeney Viktória
levelező szerző:
Jeney Viktória
kiadás éve:
2024
típus:
folyóiratcikk
műfaj:
idegen nyelvű folyóiratközlemény külföldi lapban
folyóirat:
Biomedicines (ISSN: 2227-9059)
nyelv:
angol
MAB:
orvostudományok, elméleti orvostudományok
tárgyszavak:
vascular calcification, valve calcification, vascular smooth muscle cell calcification, valve interstitial cell calcification, calcification inducers, calcification detection
absztrakt:
Cardiovascular calcification, characterized by hydroxyapatite deposition in the arterial wall and heart valves, is associated with high cardiovascular morbidity and mortality. Cardiovascular calcification is a hallmark of aging but is frequently seen in association with chronic diseases, such as chronic kidney disease (CKD), diabetes, dyslipidemia, and hypertension in the younger population as well. Currently, there is no therapeutic approach to prevent or cure cardiovascular calcification. The pathophysiology of cardiovascular calcification is highly complex and involves osteogenic differentiation of various cell types of the cardiovascular system, such as vascular smooth muscle cells and valve interstitial cells. In vitro cellular and ex vivo tissue culture models are simple and useful tools in cardiovascular calcification research. These models contributed largely to the discoveries of the numerous calcification inducers, inhibitors, and molecular mechanisms. In this review, we provide an overview of the in vitro cell culture and the ex vivo tissue culture models applied in the research of cardiovascular calcification.
pályázatok:
BO/00443/21; MTA-DE Lendület 96050; NKFIH K146669; ÚNKP-23-5-DE-499
DEENK Debreceni Egyetem
© 2012 Debreceni Egyetem